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MOTS-c is a research peptide derived from mitochondria and composed of 16 amino acids (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg). Encoded within the mitochondrial 12S rRNA gene, it regulates cellular metabolism through AMPK activation and mitochondrial homeostasis in preclinical studies. MOTS-c is widely used in metabolic and aging research investigating mitochondrial signaling, stress adaptation, and energy regulation mechanisms.
For research use only. Not for human consumption.
Shipping & Delivery Information
Our peptides undergo a careful handling, verification, and packaging process to ensure quality and integrity before shipment.
Delivery time typically ranges from 3 to 15 business days, depending on your location and the shipping method selected at checkout.
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We are committed to delivering your order as quickly as possible while maintaining the highest standards of quality and care.
Dosing & Reconstitution Guide
Educational guide for reconstitution and daily dosing
Standard / Gradual Approach (3 mL = ~13.33 mg/mL)
Week
Daily Dose (mcg)
Units (per injection) (mL)
Weeks 1–2
200 mcg (0.2 mg)
1.5 units (0.015 mL)
Weeks 3–4
400 mcg (0.4 mg)
3 units (0.03 mL)
Weeks 5–6
600 mcg (0.6 mg)
4.5 units (0.045 mL)
Weeks 7–8
800 mcg (0.8 mg)
6 units (0.06 mL)
Weeks 9–10+
1,000 mcg (1.0 mg)
7.5 units (0.075 mL)
Frequency: Inject once daily subcutaneously. Stay at each dose level for approximately 2 weeks before increasing , and monitor for any adverse reactions.
For ≤10‑unit (≤0.10 mL) administrations, consider 30‑ or 50‑unit insulin syringes for improved readability.
Reconstitution Steps
Draw 3.0 mL bacteriostatic water with a sterile syringe.
Inject slowly down the vial wall; avoid foaming.
Gently swirl/roll until dissolved (do not shake vigorously).
Label with reconstitution date and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Use within 7 days for optimal potency.
Supplies Needed
Plan based on an 8–16-week daily protocol with gradual titration.
Peptide Vials (MOTS-C, 40 mg each):
8 weeks ≈ 1 vial
12 weeks ≈ 2 vials
16 weeks ≈ 3 vials
Insulin Syringes (U‑100):
Per week: 7 syringes (1/day)
8 weeks: 56 syringes
12 weeks: 84 syringes
16 weeks: 112 syringes
Bacteriostatic Water (10 mL bottles):Use ~3.0 mL per vial for reconstitution.
8 weeks (1 vial): 3 mL → 1 × 10 mL bottle
12 weeks (2 vials): 6 mL → 1 × 10 mL bottle
16 weeks (3 vials): 9 mL → 1 × 10 mL bottle
Alcohol Swabs:One for the vial stopper + one for the injection site each day.
Goal: Support metabolic homeostasis, insulin sensitivity, and age-related physical performance based on preclinical evidence.
Schedule: Daily subcutaneous injections for 8–12 weeks (extend to 16 weeks if desired).
Dose Range: 200–1,000 mcg daily with gradual titration over 10 weeks.
Reconstitution: 3.0 mL per 40 mg vial (~13.33 mg/mL) for accurate unit measurements.
Storage: Lyophilized frozen at −20 °C (−4 °F); reconstituted refrigerated at 2–8 °C (35.6–46.4 °F); avoid repeated freeze–thaw.
Dosing Protocol
Suggested daily titration approach based on animal-to-human extrapolation.
Start: 200 mcg daily for 2 weeks.
Titration: Increase by ~200 mcg every 2 weeks: 400 mcg (Weeks 3–4), 600 mcg (Weeks 5–6), 800 mcg (Weeks 7–8).
Target: Up to 1,000 mcg (1.0 mg) daily by Weeks 9–10+ if well tolerated.
Frequency: Once per day (subcutaneous).
Cycle Length: 8–12 weeks; optional extension to 16 weeks.
Timing: Any consistent time; rotate injection sites.
Storage Instructions
Proper storage preserves peptide quality and potency.
Lyophilized: Store at −20 °C (−4 °F) or below in dry, dark conditions; include desiccant if available to minimize moisture exposure.
Reconstituted: Refrigerate at 2–8 °C (35.6–46.4 °F); peptide degrades rapidly at room temperature (~25% activity loss after 24 hours at 4 °C). Use within 7 days for best potency.
Aliquoting: Prepare single-use aliquots and freeze at −20 °C (−4 °F) if needed; avoid freeze–thaw cycles.
Allow vials to reach room temperature before opening to reduce condensation uptake.
Important Notes
Practical considerations for consistency and safety.
Use new sterile insulin syringes for each injection; dispose in a sharp’s container.
Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation and prevent lip hypertrophy.
Inject slowly; wait a few seconds before withdrawing the needle.
Document daily dose, injection site, and any observations to maintain consistency.
Discontinue use and consult a medical professional if any concerning symptoms arise.
Potential Benefits & Side Effects
Observations from preclinical literature (no human clinical trials completed to date):
Metabolic Health: Improves insulin sensitivity and glucose metabolism in mouse models; prevents diet-induced insulin resistance.
Weight & Fat Reduction: Prevents obesity and reduces visceral fat in obese mice through increased energy expenditure and fat oxidation.
Post-Menopausal Metabolism: Mitigates metabolic decline in ovariectomized mice; prevents menopause-related fat gain and insulin resistance.
Physical Performance: Enhances exercise capacity and counters age-related frailty; old mice ran 2× longer on treadmill tests.
Organ Protection: Reduces liver fat accumulation, improves cardiac function, and may support cognitive function in preliminary studies.
Bone & Immunity: Promotes osteoblast activity, inhibits osteoclast formation; modulates immune aging and protects pancreatic islet cells in autoimmune diabetes models.
Safety: No adverse effects reported in preclinical studies; human tolerability unknown. A modified analog (CB4211) showed good tolerability in a Phase 1 trial.
Note: These benefits have been demonstrated only in controlled research settings (mice or cells). Translation to humans requires clinical studies.
Lifestyle Factors
Complementary strategies for best outcomes based on MOTS-c’s metabolic mechanisms.
Pair with a balanced, protein-forward diet tailored to energy needs.
Combine resistance training and aerobic activity to reinforce metabolic adaptations and AMPK signaling.
Prioritize sleep (7–9 hours) and stress management to support mitochondrial health and recovery.
Consider intermittent fasting or caloric restriction, which may synergize with MOTS-c’s AMPK-mediated effects.
Injection Technique
General subcutaneous guidance from clinical best‑practice resources:
Clean the vial stopper and skin with alcohol; allow to dry completely.
Pinch a skinfold; insert the needle at 90° (45° if very lean) into subcutaneous tissue.
Do not aspirate for subcutaneous injections; inject slowly and steadily over a few seconds.
Withdraw needle at the same angle; apply gentle pressure if bleeding occurs (do not rub).
Rotate sites systematically (abdomen at least 2 inches from navel, outer thighs, back of upper arms) to avoid irritation and lip hypertrophy.
Dispose of used syringes immediately in a proper sharp’s container (never reuse needles).
Additional information
Select
5MG, 10MG, 20MG
Research Applications
In the scientific literature, MOTS-c has been referenced in non-clinical research involving cellular assays and animal model studies. These publications describe experimental contexts in which molecular interactions, signaling components, and pathway-associated markers were observed and recorded.
Reported research contexts include examination of:
Nuclear translocation phenomena under experimental conditions
AMPK-associated signaling elements
Metabolic pathway-related molecular markers
Gene expression patterns evaluated in cellular and animal models
All reported applications are confined to descriptive investigation within controlled laboratory research environments.
⚠️ Important Warnings and Disclaimers
Product Guidelines
Product intended for experimental and research purposes only.
Do not use without proper technical knowledge.
Keep refrigerated as per storage guidelines.
Results may vary based on genetics, diet, and lifestyle.
Keep out of reach of children.
Store according to technical instructions.
Do not reuse vials or materials.
Do not purchase if you have any doubts regarding its use.
Limitation of Liability The company is not responsible for:
Misuse or incorrect administration.
Adverse reactions or interactions with other medications.
Consequences resulting from self-medication.
The buyer assumes full responsibility for all risks associated with handling and utilization.
📌 Legal Compliance This product is marketed as a research chemical, in compliance with international laboratory supply practices. The sale of this product does not constitute an offer for medical treatment.
